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In oxidative stress-induced mitophagy, the level of ROS can be increased, further inducing mitophagy to form a positive feedback regulation [22]

This anatomical distinction underlies the concept of dual serotoninergic systems: over 90% of the bodys 5-HT is produced in the periphery (primarily in the gut), while CNS-derived 5-HT acts as a key neurotransmitter (Loh et al., 2024)

Regulation on the responses of the immune system is the way through which gut microbiota influence MS

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