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Major evidence gaps include lack of dose standardization, variable MSC characterization, short follow-up durations, and limited long-term safety data

TME-targeting theranostic agent uses NIR tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity

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This hypothesis is supported by a study demonstrating compositional gut microbiome differences between premenopausal women ( n = 44) and men ( n = 42) that were considerably less pronounced between postmenopausal women ( n = 45) and men ( n = 48) (66)

As such, metabolic enzymes associated with reactions in specific models may be targeted to complete the metabolic reaction network