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In stage IV melanoma, first clinical trials showed that adding a tumor-antigen-pulsed DC vaccine to TIL therapy was feasible and safe and enhanced antigen-specific T-cell responses, although ORRs did not clearly exceed those expected with TIL therapy alone [71, 72]

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The elevation of ROS levels and dysregulation of redox homeostasis affect numerous intracellular processes and machineries such as gene expression, energy metabolism, molecular signaling, and epigenetic modifications 22

However, the challenges encountered can vary significantly across different types of nanoparticles, which necessitates tailored regulatory approaches [164]