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doi: 10.1101/gr.126516.111 90 KosticADGeversDPedamalluCSMichaudMDukeFEarlAMet al

sometimes used for chronic pain, migraine prevention Nortriptyline (Pamelor) Moderate weight gain, less than amitriptyline Still has metabolic risks Clinical use: Sometimes used for depression when SSRIs fail, neuropathic pain Imipramine (Tofranil) Moderate weight gain Associated with metabolic syndrome in longitudinal studies Clinical use: Occasionally for treatment-resistant depression, bedwetting in children Doxepin (Sinequan) Significant weight gain Very sedating Clinical use: Sometimes used for insomnia at very low doses (Silenor) Clomipramine (Anafranil) Moderate to significant weight gain Clinical use: OCD (FDA-approved), sometimes treatment-resistant depression Overall TCA assessment: TCAs as a class carry the highest metabolic risk

Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice

Wet Bulb Temperature Wet Bulb is the temperature a parcel of air would have if cooled to saturation (100% relative humidity) by evaporation