dihexa derived from angiotensin iv Dihexa Peptide Therapy | Cognitive

S., & Ponesakki, G

Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable

However, there are now several selective -opioid receptor agonists available, including peptides such as DPDPE and deltorphin II, and non-peptide drugs such as SNC-80, [23] the more potent (+)-BW373U86, [24] a newer drug DPI-287, which does not produce the problems with convulsions seen with the earlier agents, [25] and the mixed / agonist DPI-3290, which is a much more potent analgesic than the more highly selective agonists

If true, this would have profound implications for longevity

Prog Neuropsychopharmacol Biol Psychiatry 35, 10221025 (2011)