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In addition, Daratumumab reduces the types of inhibitory cells in the TME of multiple myeloma, i.e., it consumes immuno-suppressive cells such as CD38 + MDSCs, Tregs, and Bregs, and enhances anti-tumor activity ( + Treg depletion and induce the proliferation and functional recovery of effector T cells ( Figure 2 )

Choline It assists in controlling cholesterol levels in the blood and in controlling weight gain by maintaining healthy cell membranes

Notably, clinical trial involving the use of Daratumumab and Atezolizumab (anti-PDL1) (NCT03023423) was also halted due to the lack of clinical efficacy ( 5 Conclusions Despite the small sample size, this study has important clinical implications in the treatment of NKTL patients

doi: 10.5114/ceji.2020.103422 66 PrakashAGoaKL

Though causation has not been established between vitamin B12 deficiency and depression, it has been found to be involved with many neurochemical pathways that potentially lead to this mental health disorder