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Furthermore, 1,25-dihydroxyvitamin D [1,25-(OH) 2 D] can enhance NRF2 accumulation by inhibiting its ubiquitin-proteasome-mediated degradation

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High doses of estrogen (1500-2000 pg/ml) administration to non-overiectomized mice ameliorated disease systems and significantly decreased the percentage of TNF or IFN producing CNS antigen-specific T Cells in both the CNS and spleen [31]