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GPx reduces lipid hydroperoxides to alcohols and hydrogen peroxide to water (Lubos et al

J Clin Endocrinol Metab 82:629633 Klinger B, Anin S, Silbergeld A, Eshet R, Laron Z (1998) Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome

5% due to alternative cytochrome P450 depending glutathione (GSH) conjugation pathway At high doses : Glucuronidation and sulfation pathways become saturated Cytochrome P450 dependent pathway becomes now more important.With depletion of hepatic glutathione, hepatotoxic, reactive, electrophilic metabolites are formed

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Taylor, W