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The Caco-2 cells incubated with mitragynine at 0.1, 1, and 10 M for 72 h showed downregulation of mRNA and protein expression of the P-gp in a concentration-dependent manner ( Evidence of alteration of cellular barrier function by mitragynine in long-term exposure is concerning

Assessment of Cryopreserved Human Hepatocytes as a Model System to Investigate Sulfation and Glucuronidation

This is because the product primarily influences acetylcholine

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Inflammatory pain Inflammatory pain manifests as spontaneous pain and pain hypersensitivity