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However, several studies also reported a lack of any effect of CoQ 10 supplementation on arterial lesions or endothelial function, despite decreased aortic lipid oxidation and increased resistance of plasma lipids to ex vivo oxidation (319, 321)

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doi: 10.1016/j.freeradbiomed.2015.07.162 Biomarkers of drug-induced acute kidney injury in the adult

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Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability