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Of note, the analysis by western blot revealed that the levels of enzymes involved in dTTP biosynthesis, like R1 and R2 subunits of ribonucleotide reductase (RNR), thymidylate synthase (TS), thymidylate kinase (TMPK), and thymidine kinase 1 (TK1), were similar in WT and T315I-Bcr-Abl cells (Supplementary Fig
Beyond psoriasis, FABP5 inhibition could be explored in other ferroptosis-linked epithelial disorders such as atopic dermatitis or radiation-induced dermatitis, where oxidative lipid damage undermines barrier integrity
