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Loss of TREM2 disrupts mTOR signaling, increases autophagy, and impairs microglial clustering around plaques, thereby worsening pathology [29, 450]

Cell Death Differentiation 28, 20292044

Meanwhile, the theories and paradigms of traditional pharmacological research predominantly focus on the direct antagonistic effects of drugs on molecular targets in diseased organs, and continue to face challenges when addressing complex diseases such as metabolism-related disorders, autoimmune diseases, tumors, and liver diseases

25 Recently, researchers found much higher levels of transition metals (e.g., iron and copper) in senescent cells than in nonsenescent or immortalized cells (Fig

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