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In addition to cGASSTING, recent evidence indicates that Z-DNA binding protein 1 (ZBP1) can act as an innate immune sensor for cytosolic Z-DNA, a structural form that can arise from damaged mtDNA

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A lipolytic reaction occurs, probably depending on impurities or other insulin preparation components, in LA lesions, which, indeed, have become less prevalent as products are more refined and now affect only 12% of insulin-treated patients [6, 22]

Obeid R, Murphy M, Sole-Navais P, et al