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Acknowledgements This work was supported by grants from the National Key Research and Development Program of China (2021YFA0909900), National Natural Science Foundation of China (52233013), Key Project of Science and Technology Commission of Zhejiang Province (2024C03083, 2024C03085 and 2024C03168), Zhejiang Universitys start-up packages, Fundamental Research Funds for the Central Universities (2021FZZX001-46), the Starry Night Science Fund at the Shanghai Institute for Advanced Study of Zhejiang University (SN-ZJU-SIAS-009) and Juvenile Diabetes Research Foundation (grant number 2-SRA-2021-1064-M-B)

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Furthermore, demyelination may also be detected in other brain regions such as hippocampus, basal ganglia, and cerebellum (Koutsoudaki et al., 2009