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It is found in foods originating from animals and in smaller amounts in some non-animal sources

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study

It highlights the importance of publishing negative data.'' Further, biotechnology company Phosphagenics which used the drug in an anti-cellulite cream Body Shaper, sold in major stores, said this week it had dumped the ingredient last November after 17 months because it was so useless yet incredibly expensive

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