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Additionally, in patients diagnosed with the CCC, the HLA types HLA-C*07:04 or HLA-DQB1*03:03 were shown to be significantly linked to ME/CFS status when using the CCC (89)

The causal link between exposure and outcome was tested using three different techniques: Inverse Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME)

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Furthermore, by ensuring that the protein is fully digested in the upper GI tract, these enzymes may help prevent undigested proteins from fermenting in the lower gut, thereby reducing the bloating, gas, and discomfort often associated with protein supplementation