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A study on diabetic myocardial ischemiareperfusion injury (IRI) showed that nuclear factor E2-related factor 2 (Nrf2) controlled the transcription of FPN1, since the Nrf2/FPN1 signal pathway was a pivotal mechanism in restricting ferroptosis (Tian et al

Glutathione is often called the body's "master antioxidant" and for good reason

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Other classical NRF2 target genes mRNA expression were also investigated by RT-PCR: Heme Oxygenase 1 (HO1) and NAD(P)H Quinone Dehydrogenase 1 (NQO1), and enzymes related to glutathione utilization, such as the Glutathione Peroxidases 1, 2 and 3 (GPx1, GPx2 and GPx3), with all of them having reduced expression in the NCI H23 compared to A549 cells (Supplementary Fig

That's not a reason to panic, but it's a reason to be supervised rather than self-directing