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Mouse models lacking Parkin or PINK1 develop motor deficits and dopaminergic neuron loss when subjected to mitochondrial stress, particularly in combination with the mutator mouse model, which accumulates mtDNA mutations due to POlG dysfunction [60]

Methimazole, an oral antithyroid medication which is a potent peroxidase and tyrosinase inhibitor, has shown depigmentation effects when applied topically and caused significant skin lightening in patients with melasma [75, 78, 96, 97]

References 1 AdeloyeD.ChuaS.LeeC.BasquillC.PapanaA.TheodoratouE.et al (2015)

Ce mcanisme plus doux rduit le risque d'hyperpigmentation rebond, un problme frquent avec les traitements claircissants agressifs, o la pigmentation rapparat, plus fonce encore, aprs l'arrt du traitement

Use niacinamide the next day to calm and hydrate your skin