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Briefly, siRNAs were diluted in 20 L of Opti-MEM I reduced serum medium (Gibco, 11058021) at the indicated concentrations

L-Glutathione, provided by Douglas Laboratories,supplies 250 mg of L-Glutathione in its reduced active form in a gelatin capsule

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Mathematical model for covalent proteolysis targeting chimeras: thermodynamics and kinetics underlying catalytic efficiency