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These policies will apply to rebate calculations beginning with the applicable period that began on October 1, 2022

Accordingly, at 410.67(d)(1) we specified that CMS would establish categories of bundled payments for OTPs for an episode of care, including categories for each type of opioid agonist and antagonist treatment medication, a category for medications not otherwise specified, and a category for episodes of care in which no medication is provided

Neuropsychopharmacology 35 : 20492059

NAC works by refilling intracellular glutathione levels, which is an important antioxidant that decreases oxidative stress and cellular damage

Karin, "ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development", Cancer cell , 2014 , 26 (3), 331