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The imbalanced cellular responses and inflammation result in the proliferation of synovial fibroblasts, the injury of synovial cartilage, the differentiation and maturation of osteoclasts, and the inhibition of osteoblasts to cause bone degradation

By modulating ferroptosis, it may be possible to restore the immune systems ability to recognize and attack tumor cells (42)

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Maximal effects typically occur at four to six weeks, with full tissue remodeling continuing over three to six months