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Superoxide dismutase activity in stored erythrocytes

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(2017) discovered another cell cycle protein, Spy1, which mediates the phosphorylation of ERK under the condition of binding to CDK

Under resting condition where there is a high NADPH/NADP + ratio, G6PD remains as an inactive monomer since NADPH binds to its allosteric site

Meanwhile, when DMPO was employed as a hydroxyl radical (OH) scavenger, a typical quadruplet EPR signal with an intensity ratio of 1:2:2:1 was observed in the HMO(D) group, directly confirming the presence of OH in the generated ROS pool (Figure 3i)