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(Reference Liu, Wang and Li25) reported -ketoglutarate, generated through glutaminolysis (glutamine glutamate -ketoglutarate), promotes M2 macrophage differentiation

Results indicate that the methylation frequencies of SIRT3, SMARCA5, and CDH1 do not differ significantly among young individuals, elderly individuals, and AD patients, suggesting that methylation of these genes is not related to aging or AD (63)