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Description

For labeling experiments with [U- 13 C]-serine, the fresh medium contained 0.6 mM [U- 13 C]-serine in DMEM

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Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal and human studies

We next optimized a NRF2 transcriptional signature resulting in a set of 59 genes based on their contribution to the model and overlap with previously reported NRF2 signatures (Figs