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Major hormonal shifts like pregnancy

Most therapeutic peptides require subcutaneous or intravenous administration

A-kinase anchoring proteins use their amphipathic helices to bind with high affinity to the regulatory subunit of Protein kinase A

This indicates that GAD67 is not only involved in maintaining metabolic levels of cellular GABA but may also contribute to the rapid vesicular accumulation of GABA in the presynaptic terminal for covering the incremental needs of synaptic neurotransmission by vesicular release into the synaptic cleft (Kanaani et al., 2010)

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