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N- formylmethionine (fMet), a metabolite in one-carbon metabolism, was identified as one of the most elevated metabolites with 145% change (p = 0.04) ( Figure 7B & 9 ), but no other metabolites present in the metabolomics profiling directly linked to the one-carbon pathway were found to be dysregulated

After importing the search results into EndNote 20.6, all duplicates were removed, and a title-abstract-screening was carried out by two independent reviewers (JL, JH)

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Urine organic acid analysis has historically been performed using GC/MS instrumentation

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