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Gregg Fonarow, MD: Dr Fonarow is a consultant for Abbott Pharmaceuticals, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Eli Lilly and Company, Janssen Pharmaceuticals, Medtronic, Merck, Novartis, and Pfizer

Monitoring Protocol: Although the trials showed no concerning laboratory changes, prudent clinical practice suggests baseline and periodic monitoring of metabolic parameters, complete blood counts, liver function, and kidney function

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Inflammation resolution, angiogenesis, cellular repair, and remodeling occur simultaneously

But according to a 2011 study, vitamin B12 overdose might paradoxically produce many of the same symptoms as deficiency