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For example, ALS presents both sporadic and familial forms, often linked to defective DNA repair, which leads to neuronal damage, premature aging, and subsequent neurodegeneration ( 2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation ( Figure 1

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All claims relate to in-vitro and animal models only

While several CYP51A1 inhibitors have shown promise in preclinical and clinical settings, their use in humans remains limited by off-target effects, structural specificity, and adverse interactions