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IR and T2DM, as core components of endocrine dysfunction, play a central role in the development and progression of MASLD, representing a broad area for ongoing research into novel therapeutic approaches [61]

(PubMed) Suh JH, Zhu BZ, deSzoeke E, Frei B, Hagen TM

A role for genetic has been demonstrated, with evidence of an increased risk of NAFL in patients with polymorphisms, like those associated to patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 and membrane bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 (4447)

doi: 10.1006/bbrc.2000.2800 17

The ability of zinc to bind preferentially to -synuclein coupled with the advent of ultrasensitive detection technologies such as the Surface Enhanced Raman Spectroscopy has led to the prospects of zinc-oxide nanoparticles as effective tools to probe the -synuclein-based biomarker for early detection of protein aggregates in the body fluid