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To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)

The effect of many drugs used to treat cancer also reflects a cumulative actioneg, the extent of binding of a drug to DNA is proportional to drug concentration and is usually irreversible

The enzyme was dissolved in phosphate-buffered saline at pH 7.4, sterilized through a 0.22-m membrane, and administered under ultrasound guidance

Interestingly, the weight loss effect of AOD-9604 did not follow the usual "more is better" principle

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