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This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

8226/S, 8226/S-CR, 8226/S-ATOR05 cells were treated with 2 M ATO for 0, 6, or 24 h, protein expression was determined by Western blot and membranes were probed with antibodies against proteins involved in the (A) antioxidant response or (B) the Bcl-2 family

This results in the transcriptional upregulation of pro-inflammatory cytokines (IL-1, TNF-, IL-6) [32], chemokines (CXCL8/IL-8, CCL2), antimicrobial peptides, and co-stimulatory molecules that enhance immune cell recruitment and activation [34]

Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels