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10.2147/DDDT.S132612 112

P., & Rodgers, K

A classical hypothesis suggests that PAECs are damaged by various environmental factors, such as chronic hypoxia or shear stress, leading to massive apoptosis

(2020) 318:C502c13

ROS-generating regulator: NOX4 In 2001, Wautier and colleagues conducted a study on human endothelial cells and discovered that nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) serve as pivotal downstream effectors of the AGE-RAGE signaling pathway, connecting the AGE-RAGE axis to ROS production within the cellular milieu (Wautier et al