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For example, patients with chronic renal failure have decreased renal clearance of digoxin but also a decreased volume of distribution

Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)

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Carnitine-dependent metabolic activities in Saccharomyces cerevisiae : three carnitine acetyltransferases are essential in a carnitine-dependent strain