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Rogler, G

The anti-diabetic actions of semaglutide include stimulation of insulin secretion, inhibition of glucagon secretion after meals and delay of gastric emptying [8]

Together with a study showing that displaced VM-progenitors with -synuclein triplication into the brain of PD rats can aggravate the disease phenotype 201 , these studies hints that direct homotopic transplantation of hMLOs may be a promising way, which can be used to explore the pathogenicity of PD by transplanting mutation-specific organoids into normal rodent models or the therapeutic effect of by grafting healthy organoids into PD-phenotypic ones

60,64 These diverse stimuli are thought to activate NLRP3 via inducing different cellular events, including K + efflux, Ca2 + signaling, mitochondrial and lysosomal damages that release substances such as reactive oxygen species, oxidized mitochondrial DNA and lysosomal proteases