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Interestingly, in ferroptosis research, ibuprofen has been shown to downregulate the Nrf2 signaling pathway, thereby inducing ferroptosis in glioblastoma cells (Gao et al., 2020)

this includes coronary heart disease, cerebrovascular disease, peripheral arterial disease [51, 52]

This chapter explores the factors that render the liver and kidney susceptible to toxicity, while also surveying typical toxic responses in these organs (e.g

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