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1 Introduction Parkinsons disease (PD) is the most common movement disorder and the second most prevalent neurodegenerative disease ( Given the incomplete understanding of PDs underlying pathological mechanisms, current therapeutic strategies primarily offer symptomatic relief rather than halting disease progression

Chronic inflammation, another hallmark of PCOS, arises from ROS-mediated activation of redox-sensitive transcription factors, which upregulate proinflammatory cytokines such as TNF-, IL-6, and CRP (71)

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However, JNK inhibitor SP600125 hindered the activation of JNK, leading to decreasing oridonin-mediated apoptosis (153)

In PTEN-deficient breast cancer, the expression of PI3K in tumor cells significantly hampers the infiltration of CD4+ and CD8+ T cells via the BMX/STAT3 signaling pathway, leading to the formation of an immune desert within tumors and facilitating tumor immune evasiveness