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This is another reason why its important to look closely at the manufacturers instructions for the product

Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

For additional clinical context, review Cleveland Clinic vitamin B12 injection information

Important limitations on this safety profile: the longest trial was 24 weeks, the total trial population is small by modern standards, and the clinical trials used oral dosing

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