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448 Moreover, energy demand changes dramatically when immune cells shift from a resting state to an active state, which often causes energy deficits when cells become senescent and, consequently, contributes to the metabolic remodeling accompanied by the altered secretion of cytokines, chemokines, and inflammatory mediators

The supplement normalized citrate synthase and complex IV activity and enhanced mitochondrial resilience to oxidative stress, particularly in children with greater developmental impairment (Hill et al., 2025)