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A key structural feature is a cyclopentanone ring resembling that in mammalian prostaglandins (surely no coincidence although the biosynthetic mechanisms are very different), but the stereochemistry of the active species has until recently been a cause of confusion

Metabolic fatty liver disease Metabolically associated fatty liver disease (MAFLD) encompasses a spectrum of liver diseases not covered by its previous terminology of nonalcoholic fatty liver disease 321 MAFLD has become the leading cause of chronic liver disease, affecting approximately 25% of the worlds population as of 2024