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The European Association for the Study of the Liver (EASL) guidelines recommend that all symptomatic patients with WD should receive a chelating agent and zinc should not be used as monotherapy[3]

Kappa opiate antagonists (navacaprant and aticaprant) are being evaluated in clinical trials, show substantial kappa receptor occupancy at clinical doses (greater than 70%) and show some improvement depressive symptoms [52]

Although the responses on the SCAR-Q were strongly supportive of the benefits of the CO 2 laser, the remaining subjects could potentially alter this conclusion

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-Glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response