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Statistical Analysis Metabolite concentrations were normalized to sample volume utilized for extraction and rescaled to set the median equal to 1

This conceptual framework provides an important biological basis for understanding how natural plant-derived compounds may improve lipid metabolic homeostasis through modulation of the gut microbiota (Figure 1)

Effects of caffeine on alcohol consumption and nicotine self-administration in rats

Further large-scale, long-term studies are warranted to better define optimal administration protocols and patient selection

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