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According to the study of Zhang, lncRNA FLVCR1-AS1 sponges miR-513c and increases c-Met expression in HCC cells, which induces HCC progression (Zhang et al., 2018a)

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aged animal comparisons, accelerated aging models, and longitudinal studies examining age-related biomarkers over time

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This not only makes the area appear darker but may also encourage frequent rubbing or scratching, which can increase pigmentation and worsen the shadowed look