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The nominations span three distinct clinical applicationsa breadth that reflects the compounds unclear mechanism of action more than its clinical validation

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2.4 Premedication and Concomitant Medications to Mitigate Toxicity Vitamin Supplementation Initiate folic acid 400 mcg to 1000 mcg orally once daily, beginning 7 days before the first dose of ALIMTA and continuing until 21 days after the last dose of ALIMTA [see Warnings and Precautions (5.1)]

In phase 1 and 2 clinical trials, these agents have been shown to increase hemoglobin in both end-stage renal disease and chronic kidney disease patients but not in anephric patients, demonstrating a renal source of the erythropoietin production even in nonfunctioning kidneys