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Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration

6 Here, we describe the discovery that a similar therapy-resistant cell state underlies the behavior of persister cells derived from a wide range of cancers and drug treatments

10.3389/fnut.2023.1155306 178

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[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Michal M, Kazakov DV, Belousova I, Bisceglia M, Zamecnik M, Mukensnabl P