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Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System Xc-) to normal and pathological glutamatergic signaling

If the antioxidant enzymes are deficient, or if ROS are produced in excessive amounts, H2O2 may accumulate in the tissues, causing oxidative protein damage and producing more ROS

20 Finally, Liang et al

For instance, it supports the induction of heme oxygenase-1 (HO-1) in lung fibroblasts, which mitigates inflammation and fibrosis [124]

In the Philippines, where glutathione injections have become popular for unproven skin whitening claims, the countrys FDA has issued a warning (as has the Philippine Dermatological Society) due to serious side effects on the central nervous system, kidneys and liver, and a life-threatening skin rash