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Since there is increased OCTN2 expression in the small intestine in response to oxidized fat, and OCTN2 binds not only carnitine but various drugs, it is suggested by the authors that OCTN2 might be harnessed to improve absorption of various drugs [112]

In another randomized study of 75 patients with breast cancer undergoing 12 cycles of post-surgical paclitaxel chemotherapy, oral daily administration of 1,200 mg or 2,400 mg NAC reduced peripheral neuropathy (2,400 mg [28.6%], 1,200 mg [61.9%], control [100%]) and improved quality of life over the 12-week period (Khalefa 2020)

Disruption of POGZ is associated with intellectual disability and autism spectrum disorders

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1994;102(1-2):R15