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A key aspect of this crosstalk is the livers secretion of hepatokines, such as fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15), which increase insulin sensitivity, 191 promote mitochondrial integrity in cardiomyocytes via the AMPK/FOXO3/SIRT3 signaling axis, 192 and suppress renal fibrosis

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The results show that the mRNA levels of both genes are significantly decreased in the NCI H23 cell line, which may explain the reduced GSH levels observed in this cell line (Fig