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Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

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[7] Gastrointestinal disorders are sometimes associated with aphthous-like stomatitis, e.g., most commonly celiac disease, but also inflammatory bowel disease such as Crohn's disease or ulcerative colitis

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