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Over time, these deposits cause localized retinal atrophy and photoreceptor dysfunction, leading to gradual central scotomas and the need for brighter light during detailed tasks

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The reactive species oxidize the different types of amino acids present in the protein and result in the generation of the protein-protein cross linkage which further results in the denaturation, loss of protein functioning, loss of transport protein and receptor functioning, and loss of enzymatic activity

Subsequently, Mileti et al