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It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60

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(1.3) treatment of adults with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma who have not received prior treatment for metastatic disease as a component of a combination regimen

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